Many drugs can affect blood glucose. Even preparations applied topically can be absorbed and cause systemic reactions.Medscape reviewed an article that appeared in the January 15 issue of American Family Physician (AFP):
Use of Topical Corticosteroids for Dermatologic Conditions Reviewed, Medscape, January 21, 2009
The authors of the AFP review had this to say about topical absorption (via Medscape's Laurie Barclay MD):
"Topically applied high- and ultra-high potency corticosteroids can be absorbed well enough to cause systemic side effects," the review authors write. "Hypothalamic-pituitary-adrenal suppression, glaucoma, septic necrosis of the femoral head, hyperglycemia, hypertension, and other systemic side effects have been reported. It is difficult to quantify the incidence of side effects caused by topical corticosteroids as a whole, given their differences in potency."If you've been on a topical steroid regimen and you've been experiencing unexpected blood glucose readings, you may want to consult with your prescribing physician.
Even over-the-counter, low-potency ointments that contain hydrocortisone, when used regularly and for longer than several months, may induce a blood glucose effect.
Dr. Barclay's advice for physicians:
"To avoid adverse effects, continuous use of low-potency to high-potency topical steroids should not exceed 3 months."
